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1.Identification
1.1 GHS Product identifier
| Product name | 2,4,6-trichlorophenol |
|---|
1.2 Other means of identification
| Product number | - |
|---|---|
| Other names | Phenaclor |
1.3 Recommended use of the chemical and restrictions on use
| Identified uses | For industry use only. 2,4,6-Trichlorophenol is no longer used in the United States. It was previously used as an antiseptic; a pesticide for wood, leather, and glue preservation; and as an anti-mildew treatment. It was also used in the manufacture of other chemicals. Production of 2,4,6-trichlorophenol was discontinued in the United States in the 1980s. |
|---|---|
| Uses advised against | no data available |
1.4 Supplier's details
1.5 Emergency phone number
| Emergency phone number | - |
|---|---|
| Service hours | Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). |
2.Hazard identification
2.1 Classification of the substance or mixture
Acute toxicity - Oral, Category 4
Skin irritation, Category 2
Eye irritation, Category 2
Carcinogenicity, Category 2
Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1
2.2 GHS label elements, including precautionary statements
| Pictogram(s) |    |
|---|---|
| Signal word | Warning |
| Hazard statement(s) | H302 Harmful if swallowed H315 Causes skin irritation H319 Causes serious eye irritation H351 Suspected of causing cancer H410 Very toxic to aquatic life with long lasting effects |
| Precautionary statement(s) | |
| Prevention | P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection. P201 Obtain special instructions before use. P202 Do not handle until all safety precautions have been read and understood. P273 Avoid release to the environment. |
| Response | P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/…if you feel unwell. P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P313 If skin irritation occurs: Get medical advice/attention. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313 If eye irritation persists: Get medical advice/attention. P308+P313 IF exposed or concerned: Get medical advice/ attention. P391 Collect spillage. |
| Storage | P405 Store locked up. |
| Disposal | P501 Dispose of contents/container to ... |
2.3 Other hazards which do not result in classification
none
3.Composition/information on ingredients
3.1 Substances
| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
|---|---|---|---|---|
| 2,4,6-trichlorophenol | 2,4,6-trichlorophenol | 88-06-2 | none | 100% |
4.First-aid measures
4.1 Description of necessary first-aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
Fresh air, rest.
In case of skin contact
Remove contaminated clothes. To remove substance use polyethylene glycol 300 or vegetable oil. Rinse and then wash skin with water and soap.
In case of eye contact
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
If swallowed
Rinse mouth. Do NOT induce vomiting. Refer for medical attention .
4.2 Most important symptoms/effects, acute and delayed
SYMPTOMS: Symptoms of exposure to this compound may include irritation of the skin, eyes, nose, throat, mucous membranes and upper respiratory tract. Contact with the skin may result in redness, edema, dermatitis and chemical burns. Contact with the eyes may result in corneal injury and iritis. It may also cause lacrimation. Other symptoms may include an increase followed by a decrease in respiratory rate and urinary output, fever, increased bowel action, weakness of movement, collapse, convulsions, lung damage, liver damage and kidney damage. Additional symptoms caused by this type of compound include painless blanching or erythema of the skin, corrosion, profuse sweating, intense thirst, nausea and vomiting, diarrhea, cyanosis from methemoglobinemia, hyperactivity, hyperthermia, skin rashes (sometimes chloracne), neurological and immunological effects, stupor, blood pressure fall, hyperpnea, abdominal pain, hemolysis, coma, and pulmonary edema followed by pneumonia. Rapid death has been reported. If death from respiratory failure is not immediate, jaundice and oliguria or anuria may occur. Skin sensitivity reactions occur occasionally. Prolonged eye contact may cause eye damage. Depending on the intensity and duration of exposure, effects may include severe destruction of tissue. ACUTE/CHRONIC HAZARDS: This compound is harmful by ingestion, inhalation and skin absorption. It is an irritant of the skin, eyes, nose, throat, mucous membranes and upper respiratory tract. When heated to decomposition it emits toxic fumes of carbon monoxide, carbon dioxide and hydrogen chloride gas. It may also emit toxic fumes of chloride ion.
4.3 Indication of immediate medical attention and special treatment needed, if necessary
Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Phenols and related compounds/
5.Fire-fighting measures
5.1 Extinguishing media
Suitable extinguishing media
If material /is/ involved in /a/ fire, extinguish fire using agent suitable for type of surrounding fire. Material itself does not burn or burns with difficulty. /Trichlorophenol/
5.2 Specific hazards arising from the chemical
Literature sources indicate that this chemical is nonflammable.
5.3 Special protective actions for fire-fighters
Wear self-contained breathing apparatus for firefighting if necessary.
6.Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.
6.2 Environmental precautions
Personal protection: filter respirator for organic gases and particulates adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
6.3 Methods and materials for containment and cleaning up
Activated carbon is a good method for removing chlorophenols from water. Competitive adsorption occurs between chlorophenols & humic substances present in nearly all municipal water supplies. This competition decr the capacity of carbon for chlorophenols. /Chlorophenols/
7.Handling and storage
7.1 Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Provision to contain effluent from fire extinguishing. Separated from strong oxidants and food and feedstuffs. Well closed. Store in an area without drain or sewer access.PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. /Chemical Carcinogens/
8.Exposure controls/personal protection
8.1 Control parameters
Occupational Exposure limit values
no data available
Biological limit values
no data available
8.2 Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
8.3 Individual protection measures, such as personal protective equipment (PPE)
Eye/face protection
Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
Respiratory protection
Wear dust mask when handling large quantities.
Thermal hazards
no data available
9.Physical and chemical properties
| Physical state | white to off-white crystalline solid |
|---|---|
| Colour | Crystals from ligroin |
| Odour | Strong phenolic odor |
| Melting point/ freezing point | 277°C(lit.) |
| Boiling point or initial boiling point and boiling range | 120°C/39mmHg(lit.) |
| Flammability | Combustible. Gives off irritating or toxic fumes (or gases) in a fire. |
| Lower and upper explosion limit / flammability limit | no data available |
| Flash point | 82°C(lit.) |
| Auto-ignition temperature | no data available |
| Decomposition temperature | no data available |
| pH | Moderately acidic substance |
| Kinematic viscosity | no data available |
| Solubility | In water:0.8 g/L |
| Partition coefficient n-octanol/water (log value) | log Kow = 3.69 |
| Vapour pressure | 1 mm Hg ( 76.5 °C) |
| Density and/or relative density | 1.49 |
| Relative vapour density | no data available |
| Particle characteristics | no data available |
10.Stability and reactivity
10.1 Reactivity
no data available
10.2 Chemical stability
Stable up to its melting point
10.3 Possibility of hazardous reactions
Non-combustible /Trichlorophenol/2,4,6-TRICHLOROPHENOL is incompatible with acid chlorides, acid anhydrides and oxidizing agents. It can be converted to the sodium salt by reaction with sodium carbonate. Forms ethers, esters and salts by reaction with metals and amines. Undergoes substitution reactions such as nitration, alkylation, acetylation and halogenation. Can be hydrolyzed by reaction with bases at elevated temperatures and pressures. Reacts with alkalis at high temperatures .
10.4 Conditions to avoid
no data available
10.5 Incompatible materials
Incompatible materials: Strong oxidizing agents.
10.6 Hazardous decomposition products
When heated to decomposition it emits toxic fumes of /hydrogen chloride/.
11.Toxicological information
Acute toxicity
- Oral: LD50 Rat oral 2.8 g/kg
- Inhalation: no data available
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
CLASSIFICATION: B2; probable human carcinogen. BASIS FOR CLASSIFICATION: Based on no human data and sufficient evidence in animals; namely, increased incidence of lymphomas or leukemia in male rats and hepatocellular adenomas or carcinomas in male and female mice. HUMAN CARCINOGENICITY DATA: None. ANIMAL CARCINOGENICITY DATA: Sufficient.
Reproductive toxicity
No studies are available on the developmental or reproductive effects of 2,4,6-trichlorophenol in humans from inhalation or oral exposure. Animal studies have reported a transient reduction in the body weight of the offspring of rats exposed to 2,4,6-trichlorophenol orally, while no other developmental effects have been noted in animal studies. Reduced mean litter size was observed in rats following maternal exposure to 2,4,6-trichlorophenol in the drinking water, while no reproductive effects were observed in other animal studies via gavage (placing the chemical experimentally in the stomach).
STOT-single exposure
no data available
STOT-repeated exposure
no data available
Aspiration hazard
no data available
12.Ecological information
12.1 Toxicity
- Toxicity to fish: LC50; Species: Lepomis macrochirus (Bluegill) 1st yr class; Concentration: 0.72 mg/L for 24 hr /Conditions of bioassay not specified in source examined
- Toxicity to daphnia and other aquatic invertebrates: EC50; Species: Daphnia magna (Water Flea) age 0-24 hr; Conditions: freshwater, flow through, 17.2 (16.5-18.4)°C, pH 7.39 (6.84-7.80), hardness 44.7 mg/L CaCO3 (40.8-47.6 mg/L CaCO3), alkalinity 43.0 mg/L CaCO3 (40.4-49.5 mg/L CaCO3), dissolved oxygen 8.7 (4.8-10.7) mg/L ; Concentration: 3340 ug/L for 48 hr (95% confidence interval: 2810-3970 ug/L); Effect: intoxication, immobilization
- Toxicity to algae: EC50; Species: Scenedesmus subspicatus (Green Algae); Conditions: freshwater, static; Concentration: 279000 ug/L for 49-79 min; Effect: population, decreased photosynthesis
- Toxicity to microorganisms: no data available
12.2 Persistence and degradability
AEROBIC: 2,4,6-Trichlorophenol biodegraded 100% in 10-14 days with an 8 day lag time in filtered water and in 8-10 days with a 2 day lag time in water with sediment(1). 2,4,6-Trichlorophenol is expected to biodegrade in aerobic soils with a biodegradation half-life of about 5 days(2). Total degradation of 2,4,6-trichlorophenol in Dunkirk silt loam took 5 days and in Mardin silt loam took 13 days(3). In Labisch soil, 2,4,6-trichlorophenol biodegraded 67% in 60 days(4). 2,4,6-Trichlorophenol was aerobically degraded 95% in 3 days and 27% in 80 days in non-sterile and sterile clay loam, respectively(5). Microbial degradation, volatilization, and photodecomposition were ruled out in the sterile soil indicating that other mechanisms contribute to degradation(5). Activated sludge made from soil resulted in 100% removal of 2,4,6-trichlorophenol in 3 days(6); sewage seed resulted in complete removal in 7 days(7); 39% removal by activated sludge in 14 days was reported(8). 2,4,6-Trichlorophenol was readily degraded in an aerobic microcosm using soils from the saturated zone(9). A 2,4-dichlorophenol-acclimated soil inoculum completely degraded an unspecified initial concentration of 2,4,6-trichlorophenol in 28 days(10). 2,4,6-Trichlorophenol, present at 1.5 mg/L, was completely degraded in 8 days using an inoculum derived from river sediment obtained near a petrochemical plant(11). The compound was 92% degraded in 30 days using an activated sludge inoculum(12). 2,4,6-Trichlorophenol, present at 100 mg/L, reached 82.5-89.3% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(13).
12.3 Bioaccumulative potential
BCFs of 250-310 were reported for Golden Orfe fish (1,2). BCFs of 87 and 676 were reported for flagfish (Jordanella floridae)(3). A BCF of 270 was also reported(4). According to a classification scheme(5), these BCF values suggest that bioconcentration in aquatic organisms is moderate to high(SRC).
12.4 Mobility in soil
The Koc values of 2,4,6-trichlorophenol in soil at pH 6, 7 and 7.7 were measured as 2200, 600 and 150 respectively(1). Koc values of 1300 and 800 were determined in river and lake sediment at an unspecified pH(2). Koc values of 2000(3), 1050(4) and 1070(5) were also reported for 2,4,6-trichlorophenol. According to a classification scheme(6), these Koc values suggest that 2,4,6-trichlorophenol is expected to have moderate to slight mobility in soil. The pKa of 2,4,6-trichlorophenol is 6.23(7), indicating that this compound will exist partially in anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(8).
12.5 Other adverse effects
no data available
13.Disposal considerations
13.1 Disposal methods
Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
14.Transport information
14.1 UN Number
| ADR/RID: UN2020 | IMDG: UN2020 | IATA: UN2020 |
14.2 UN Proper Shipping Name
| ADR/RID: CHLOROPHENOLS, SOLID |
| IMDG: CHLOROPHENOLS, SOLID |
| IATA: CHLOROPHENOLS, SOLID |
14.3 Transport hazard class(es)
| ADR/RID: 6.1 | IMDG: 6.1 | IATA: 6.1 |
14.4 Packing group, if applicable
| ADR/RID: III | IMDG: III | IATA: III |
14.5 Environmental hazards
| ADR/RID: yes | IMDG: yes | IATA: yes |
14.6 Special precautions for user
no data available
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
no data available
15.Regulatory information
15.1 Safety, health and environmental regulations specific for the product in question
| Chemical name | Common names and synonyms | CAS number | EC number |
|---|---|---|---|
| 2,4,6-trichlorophenol | 2,4,6-trichlorophenol | 88-06-2 | none |
| European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. | ||
| EC Inventory | Listed. | ||
| United States Toxic Substances Control Act (TSCA) Inventory | Listed. | ||
| China Catalog of Hazardous chemicals 2015 | Listed. | ||
| New Zealand Inventory of Chemicals (NZIoC) | Listed. | ||
| Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Listed. | ||
| Vietnam National Chemical Inventory | Not Listed. | ||
| Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Listed. | ||
16.Other information
Information on revision
| Creation Date | Aug 12, 2017 |
|---|---|
| Revision Date | Aug 12, 2017 |
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/