1.Identification

1.1 GHS Product identifier

1.2 Other means of identification

1.3 Recommended use of the chemical and restrictions on use

1.4 Supplier's details

1.5 Emergency phone number

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 4

Carcinogenicity, Category 2

Specific target organ toxicity – repeated exposure, Category 2

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word	Warning
Hazard statement(s)	H302 Harmful if swallowed H351 Suspected of causing cancer H410 Very toxic to aquatic life with long lasting effects
Precautionary statement(s)
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P201 Obtain special instructions before use. P202 Do not handle until all safety precautions have been read and understood. P280 Wear protective gloves/protective clothing/eye protection/face protection. P260 Do not breathe dust/fume/gas/mist/vapours/spray. P273 Avoid release to the environment.
Response	P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/…if you feel unwell. P330 Rinse mouth. P308+P313 IF exposed or concerned: Get medical advice/ attention. P314 Get medical advice/attention if you feel unwell. P391 Collect spillage.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact

Wash off with soap and plenty of water. Consult a physician.

In case of eye contact

Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed

Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2 Most important symptoms/effects, acute and delayed

INHALATION: May cause irritation of nose and throat. EYES: Irritation. SKIN: Moderately irritating to skin. (USCG, 1999)

4.3 Indication of immediate medical attention and special treatment needed, if necessary

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

Use dry chemical, CO2, water spray, or foam extinguishers ... If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Notify local health and fire officials and pollution control agencies. From a secure, explosion-proof location, use water spray to cool exposed containers. If cooling streams are ineffective (venting sound increases in volume and pitch, tank discolors or shows any digns of deforming), withdraw immediately to a secure position ... The only respirators recommended for fire fighting are self-contained breathing apparatuses that have full face-pieces and are operated in a pressure-demand or other positive-pressure mode.

5.2 Specific hazards arising from the chemical

Special Hazards of Combustion Products: Highly toxic fumes are imminent Behavior in Fire: Decomposes at 180° to 190°C (USCG, 1999)

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

6.3 Methods and materials for containment and cleaning up

Spill handling: evacuate persons not wearing protective equipment from area of spill or leak until clean-up is complete. Remove all ignition sources. Collect powdered material in the most convenient and safe manner and deposit in sealed containers. Ventilate area after clean-up is complete. It may be necessary to contain and dispose of this chemical as a hazardous waste. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Contact your Department of Environmental Protection or your regional office of the federal EPA for specific recommendations.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Store in tightly closed containers in a cool, well-ventilated area.

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

Recommended Exposure Limit: 10 Hour Time-Weighted Average: 10 mg/cu m.

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Stable for 2 yrs. in double polyethylene bag inside a fiber drum under warehouse conditions.

10.3 Possibility of hazardous reactions

May burn, but not readily flammable.DIURON is incompatible with the following: Strong acids (NIOSH, 2016).

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

Treatment at elevated temperatures by acid or base yields dimethylamine and 3,4-dichloroaniline.

10.6 Hazardous decomposition products

Diuron, stable under normal conditions, decomposed on heating to 180 to 190°C giving dimethylamine and 3,4-dichlorophenyl isocyanate.

11.Toxicological information

Acute toxicity

• Oral: LD50 Rat (male) oral 3400 mg/kg
• Inhalation: LC50 Rat inhalation > 0.265 mg/L for 4 hr
• Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

Cancer Classification: Known/ Likely /to be Carcinogenic to Humans/

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

• Toxicity to fish: LC50; Species: Lepomis macrochirus (Bluegill), weight 0.8 g; Concentration: 8.2 mg/L/96 hr (95% confidence limit 7.4 - 9.1 mg/L); Conditions: static bioassay without aeration, temperature 18°C, pH 7.2-7.5, water hardness 40-50 mg/L as calcium carbonate, alkalinity 30-35 mg/L
• Toxicity to daphnia and other aquatic invertebrates: LC50; Species: Daphnia magna (water flea); Concentration: 1400 ug/L/24 hr /Conditions of bioassay not specified
• Toxicity to algae: LC50; Species: Scenedesmus subspicatus (algae); Concentration: 0.022 mg/L for 4 days; Conditions: temperature 23°C
• Toxicity to microorganisms: no data available

12.2 Persistence and degradability

AEROBIC: Diuron, present at 100 mg/L, reached 0% of its theoretical BOD in 4 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(1). In a Zahn-Wellens inherent biodegradability test, 50 mg/L of diuron was found to be not inherently biodegradable with 0% degradation in activated sludge inoculum after 28 days(2). Degradation of diuron in natural soils was found to be slow and incomplete(3). Inoculation of a sandy C-horizon with a diuron-degrading bacterial strain led to substantial diuron degradation, but the addition of purified fulvic acid and humic acid to these inoculated soils decreased this degradation, suggesting that adsorption to humic substances in soil hinders degradation(3). In soil, enzymatic and microbial demethylation of the nitrogen atom and hydroxylation at position 2 of the benzene ring occurs. Duration of activity in soil is about 4 to 8 months, depending on soil type and humidity, with a half-life of 90 to 180 days(4). In a 22 week laboratory study conducted at 27°C and 60% relative humidity, approximately 40% degradation occurred in Cecil loamy sand (1 ppm applied 4 times) and Brookstone silty clay loam (5 ppm applied 4 times)(5). Biological degradation in soil increased with increasing temperature and decreased with increasing concentration; little degradation was noted at 0°C in 20 weeks whereas substantial degradation occurred in 10 weeks in two soils at 10 ppm and only in one at 15 ppm when incubated at 20°C(6,7). Less than 20% of diuron (60 ppm) added to soil was detoxified within 8 weeks and there was little effect on the degradation rate when the soils were titrated to different pH's between 4.3 and 7.5(8). Degradation of diuron in soil was stimulated by amendment of the soil with manure but inhibited by sludge amendment(9).

12.3 Bioaccumulative potential

BCF values of 3.4 to 4.9 and <2.9 to 14 were measured in fish for diuron at concentrations of 0.5 and 0.05 mg/L, respectively, using carp (Cyprinus carpio) which were exposed over an 6-week period(1). According to a classification scheme(2), these BCF values indicate that bioconcentration in aquatic organisms is low(SRC).

12.4 Mobility in soil

The mean value and standard deviation of Koc for diuron compiled from the published literature for 84 soils is 383 and 72 respectively(1). Other Koc experimental values for diuron are: Webster soil, 682(2); mucky peat soil, 879(3); loamy sand soil, 478(3); two subsurface soils from Oklahoma, 224 and 371(4); 480 (5); 400 (6); aquifer sediments, range 69-266(7). In 43 surface soil samples representing a range of soil physicochemical properties collected from dry and wet zones of Sri Lanka, measured Koc values for diuron ranged from 55.3 to 962 (mean, 407; median, 328), while soils from dry zones were 1.5 times higher than those from the wet zone(8). In three representative cotton soils, a red sandy soil, a black cracking clay, and a brown loam, of North West New South Wales, Australia, diuron had Koc values of 457, 488, and 498, respectively(9). According to a classification scheme(10), these measured Koc values suggest that diuron is expected to have moderate to low mobility in soil.

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

14.2 UN Proper Shipping Name

14.3 Transport hazard class(es)

14.4 Packing group, if applicable

14.5 Environmental hazards

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

16.Other information

Information on revision

Abbreviations and acronyms

• CAS: Chemical Abstracts Service
• ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
• RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
• IMDG: International Maritime Dangerous Goods
• IATA: International Air Transportation Association
• TWA: Time Weighted Average
• STEL: Short term exposure limit
• LC50: Lethal Concentration 50%
• LD50: Lethal Dose 50%
• EC50: Effective Concentration 50%

References

• IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
• HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
• IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
• eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
• CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
• ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
• ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
• Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
• ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.