Xn:Harmful
1.Identification
1.1 GHS Product identifier
| Product name | N-nitrosodiethylamine |
|---|
1.2 Other means of identification
| Product number | - |
|---|---|
| Other names | Diethylnitrosoamine |
1.3 Recommended use of the chemical and restrictions on use
| Identified uses | For industry use only. |
|---|---|
| Uses advised against | no data available |
1.4 Supplier's details
1.5 Emergency phone number
| Emergency phone number | - |
|---|---|
| Service hours | Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). |
2.Hazard identification
2.1 Classification of the substance or mixture
Acute toxicity - Oral, Category 3
Carcinogenicity, Category 1B
2.2 GHS label elements, including precautionary statements
| Pictogram(s) |   |
|---|---|
| Signal word | Danger |
| Hazard statement(s) | H301 Toxic if swallowed H350 May cause cancer |
| Precautionary statement(s) | |
| Prevention | P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P201 Obtain special instructions before use. P202 Do not handle until all safety precautions have been read and understood. P280 Wear protective gloves/protective clothing/eye protection/face protection. |
| Response | P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor/… P321 Specific treatment (see ... on this label). P330 Rinse mouth. P308+P313 IF exposed or concerned: Get medical advice/ attention. |
| Storage | P405 Store locked up. |
| Disposal | P501 Dispose of contents/container to ... |
2.3 Other hazards which do not result in classification
none
3.Composition/information on ingredients
3.1 Substances
| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
|---|---|---|---|---|
| N-nitrosodiethylamine | N-nitrosodiethylamine | 55-18-5 | none | 100% |
4.First-aid measures
4.1 Description of necessary first-aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
4.2 Most important symptoms/effects, acute and delayed
ACUTE/CHRONIC HAZARDS: When heated to decomposition this compound emits toxic fumes of nitrogen oxides.
4.3 Indication of immediate medical attention and special treatment needed, if necessary
Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Organic bases/Amines and related compounds/
5.Fire-fighting measures
5.1 Extinguishing media
Suitable extinguishing media
Use dry chemical, carbon dioxide, alcohol foam, or polymer foam extinguishers.
5.2 Specific hazards arising from the chemical
This chemical is combustible.
5.3 Special protective actions for fire-fighters
Wear self-contained breathing apparatus for firefighting if necessary.
6.Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.
6.2 Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.
6.3 Methods and materials for containment and cleaning up
SPILLS ... ABSORBED BY CELITE (R) OR COMMERCIAL SPILL ABSORBANT. AFTER ABSORBANT CONTAINING MAJOR SHARE OF NITROSOAMINE ... PICKED UP (AVOID DUSTS; DO NOT SWEEP), SURFACE SHOULD BE THOROUGHLY CLEANED WITH STRONG DETERGENT SOLN. IF MAJOR SPILL OCCURS OUTSIDE OF VENTILATED AREA, ROOM SHOULD BE EVACUATED & CLEANUP OPERATION SHOULD BE CARRIED OUT BY PERSONS EQUIPPED WITH SELF-CONTAINED RESPIRATORS. THOSE INVOLVED IN THIS OPERATION SHOULD WEAR RUBBER GLOVES, LAB COATS, & PLASTIC APRONS OR EQUIVALENT PROTECTIVE APPAREL.
7.Handling and storage
7.1 Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
ALL BOTTLES ... SHOULD BE STORED & TRANSPORTED WITHIN AN UNBREAKABLE OUTER CONTAINER; STORAGE SHOULD BE IN VENTILATED STORAGE CABINET OR IN HOOD.
8.Exposure controls/personal protection
8.1 Control parameters
Occupational Exposure limit values
no data available
Biological limit values
no data available
8.2 Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
8.3 Individual protection measures, such as personal protective equipment (PPE)
Eye/face protection
Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
Respiratory protection
Wear dust mask when handling large quantities.
Thermal hazards
no data available
9.Physical and chemical properties
| Physical state | yellow liquid |
|---|---|
| Colour | Slightly yellow liquid |
| Odour | no data available |
| Melting point/ freezing point | 29°C(lit.) |
| Boiling point or initial boiling point and boiling range | 177°C(lit.) |
| Flammability | no data available |
| Lower and upper explosion limit / flammability limit | no data available |
| Flash point | 85°C(lit.) |
| Auto-ignition temperature | no data available |
| Decomposition temperature | no data available |
| pH | no data available |
| Kinematic viscosity | no data available |
| Solubility | greater than or equal to 100 mg/mL at 21.11°C |
| Partition coefficient n-octanol/water (log value) | log Kow = 0.48 |
| Vapour pressure | 5.7 mm Hg at 25°C ; 8.8 mm Hg at 34.5°C |
| Density and/or relative density | 0.95g/mL(lit.) |
| Relative vapour density | no data available |
| Particle characteristics | no data available |
10.Stability and reactivity
10.1 Reactivity
no data available
10.2 Chemical stability
STABLE AT ROOM TEMP FOR SEVERAL DAYS IN AQ SOLN @ NEUTRAL & ALKALINE PH; LESS STABLE @ STRONGLY ACID PH @ ROOM TEMP
10.3 Possibility of hazardous reactions
N-NITROSODIETHYLAMINE reacts with strong oxidizing agents. Incompatible with reducing agents. Can be hydrolyzed by hydrogen bromide in acetic acid .
10.4 Conditions to avoid
no data available
10.5 Incompatible materials
Oxidizers, reducing agents (may form hydrazine), and hydrogen bromide. Light sensitive, rapidaly decomposes.
10.6 Hazardous decomposition products
When heated to decomposition it emits toxic fumes of /oxides of nitrogen/.
11.Toxicological information
Acute toxicity
- Oral: LD50 Rat oral 280 mg/kg
- Inhalation: no data available
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
No data are available in humans. Sufficient evidence of carcinogenicity in animals. OVERALL EVALUATION: Group 2A: The agent is probably carcinogenic to humans.
Reproductive toxicity
no data available
STOT-single exposure
no data available
STOT-repeated exposure
no data available
Aspiration hazard
no data available
12.Ecological information
12.1 Toxicity
- Toxicity to fish: LC50; Species: Pimephales promelas (Fathead Minnow); Conditions: freshwater, static, 22.0-23.0°C, pH 8.07-8.25, hardness 288 mg/L CaCO3, dissolved oxygen 4.8-7.0 mg/L; Concentration: 775000 ug/L for 96 hr (95% confidence interval: 698000-860000 ug/L)
- Toxicity to daphnia and other aquatic invertebrates: no data available
- Toxicity to algae: EC50; Species: Anabaena flosaquae (Blue-Green Algae) 10000 cells; Conditions: freshwater, static, 24°C; Concentration: 17500 ug/L for 96 hr; Effect: growth, general
- Toxicity to microorganisms: no data available
12.2 Persistence and degradability
AEROBIC: The concentration of N-nitrosodiethylamine (18.0 ppm nitroso-N) in lake water was essentially unchanged after 108 days incubation in the dark at 30°C. While the level of N-nitrosodiethylamine amended with raw sewage at pH 6.0 slowly decreased from approximately 17 ppm to 12 ppm over 14 days; the fact that the decrease was nearly the same in sterilized samples indicates that abiotic factors may have been responsible for the loss. At pH 7.2 the rate of loss was greater than for autoclaved sewage, however heat treatment may have altered sample properties so that nonbiological loss was diminished(1).
12.3 Bioaccumulative potential
An estimated BCF of 3 was calculated in fish for N-nitrosodiethylamine(SRC), using a log Kow of 0.48(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).
12.4 Mobility in soil
Using a structure estimation method based on molecular connectivity indices(1), the Koc of N-nitrosodiethylamine can be estimated to be 83(SRC). The Koc of N-nitrosodiethylamine can be estimated as 14(SRC), using a log Kow of 0.48(2) and a regression-derived equation(1). According to a classification scheme(3), these estimated Koc values suggest that N-nitrosodiethylamine is expected to have very high to high mobility in soil.
12.5 Other adverse effects
no data available
13.Disposal considerations
13.1 Disposal methods
Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
14.Transport information
14.1 UN Number
| ADR/RID: UN2810 | IMDG: UN2810 | IATA: UN2810 |
14.2 UN Proper Shipping Name
| ADR/RID: TOXIC LIQUID, ORGANIC, N.O.S. |
| IMDG: TOXIC LIQUID, ORGANIC, N.O.S. |
| IATA: TOXIC LIQUID, ORGANIC, N.O.S. |
14.3 Transport hazard class(es)
| ADR/RID: 6.1 | IMDG: 6.1 | IATA: 6.1 |
14.4 Packing group, if applicable
| ADR/RID: III | IMDG: III | IATA: III |
14.5 Environmental hazards
| ADR/RID: no | IMDG: no | IATA: no |
14.6 Special precautions for user
no data available
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
no data available
15.Regulatory information
15.1 Safety, health and environmental regulations specific for the product in question
| Chemical name | Common names and synonyms | CAS number | EC number |
|---|---|---|---|
| N-nitrosodiethylamine | N-nitrosodiethylamine | 55-18-5 | none |
| European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. | ||
| EC Inventory | Listed. | ||
| United States Toxic Substances Control Act (TSCA) Inventory | Listed. | ||
| China Catalog of Hazardous chemicals 2015 | Not Listed. | ||
| New Zealand Inventory of Chemicals (NZIoC) | Not Listed. | ||
| Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Not Listed. | ||
| Vietnam National Chemical Inventory | Not Listed. | ||
| Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Not Listed. | ||
16.Other information
Information on revision
| Creation Date | Aug 12, 2017 |
|---|---|
| Revision Date | Aug 12, 2017 |
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/