Polymyxin B sulfate, chemically identified as N-[4-amino-1-[[1-[[4-amino-1-oxo-1-[[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methyloctanamide;sulfuric acid, is a cyclic peptide antibiotic predominantly used to combat multi-drug resistant Gram-negative bacterial infections. Its mechanism of action involves disrupting the bacterial cell membrane, leading to cell death. Polymyxin B sulfate has been widely used in clinical settings, particularly for its efficacy against infections resistant to other antibiotics. However, its clinical application is often limited by its nephrotoxicity, which necessitates careful monitoring of kidney function during treatment. Recent studies have compared its safety profile with colistin sulfate, another polymyxin, and found polymyxin B sulfate to be associated with a higher incidence of acute kidney injury (AKI). Despite this, both drugs have shown similar efficacy in treating resistant infections. Innovative formulations, such as polymyxin B sulfate inhalable microparticles combined with high-lectin-affinity sugars, have been developed to enhance treatment of biofilm-associated pulmonary infections. These formulations improve drug delivery to lung lesions and disrupt biofilm structures, enhancing the antibiotic's effectiveness while potentially reducing systemic toxicity. The continuous development of such advanced delivery systems aims to maximize the therapeutic benefits of polymyxin B sulfate while mitigating its adverse effects.
There are many suppliers of Polymyxin B sulfate on the LookChem platform, such as NANJING SUNNY PHARMATECH CO., LTD, Josun International Limited, Hubei Centro pharmaceutical Co., Ltd. Through the form on the right, you can choose to send an inquiry to your intended factory. We recommend that you clearly describe your purchase requirements, for example: Polymyxin B sulfate CAS number 1405-20-5 with a purity of over 98% that needs to be transported to Los Angeles, USA.
Here are some small packages of Polymyxin B sulfate price information you can contact us to purchase, if you need to purchase Polymyxin B sulfate in bulk, please send an inquiry message to get the latest prices and offers.
| Name | CAS | Size | Price(USD) |
| MACKLIN | 1405-20-5 | 5.00g | 90.90 |
| MACKLIN | 1405-20-5 | 25.00g | 431.19 |
| MACKLIN | 1405-20-5 | 1.00g | 36.12 |
| MACKLIN | 1405-20-5 | 100.00g | 1074.63 |
| Acmec | 1405-20-5 | 25.00g | 343.13 |
| Acmec | 1405-20-5 | 5.00g | 89.40 |
| Acmec | 1405-20-5 | 100.00mg | 11.79 |
| Acmec | 1405-20-5 | 1.00g | 52.09 |
| Picasso-e | 1405-20-5 | 25.00g | 909.55 |
| Picasso-e | 1405-20-5 | 5.00g | 190.90 |
| Picasso-e | 1405-20-5 | 1.00g | 76.87 |
| Picasso-e | 1405-20-5 | 250.00mg | 35.07 |
| Boer | 1405-20-5 | 5.00g | 87.31 |
| Boer | 1405-20-5 | 1.00g | 38.06 |
| Boer | 1405-20-5 | 25.00g | 413.88 |
| Boer | 1405-20-5 | 1.00G | 147.76 |
| Boer | 1405-20-5 | 5.00G | 595.52 |
| Psaitong | 1405-20-5 | 5.00g | 77.61 |
| Psaitong | 1405-20-5 | 25.00g | 320.90 |
| Psaitong | 1405-20-5 | 1.00g | 35.82 |