Chemicals used in cancer treatment
Vincristine sulfate is a sulfate salt of vincristine, an alkaloid derived from the plant Catharanthus roseus, known for its antimitotic and antineoplastic properties. It works by binding to microtubules and spindle proteins, disrupting mitotic spindle formation, and arresting cells in metaphase, which is critical in cancer treatment. Vincristine sulfate is used primarily to treat acute lymphocytic leukemia, Hodgkin's and non-Hodgkin's lymphoma, and various solid tumors. Despite its efficacy, vincristine sulfate has significant biopharmaceutical limitations, such as a short serum half-life and extensive protein binding, necessitating frequent dosing. To address these issues, novel delivery systems have been developed, including dextran microspheres combined with thermosensitive gels and ultra-small, reduction-sensitive polymersomes. These systems enhance vincristine sulfate's stability, sustain its release, and improve its therapeutic potential by targeting specific cancer cell markers, such as CD44 in acute myeloid leukemia, and overcoming multidrug resistance via P-glycoprotein inhibition. Advanced encapsulation methods, such as PLGA nanoparticles and multifunctional nanoassemblies, have been utilized to improve vincristine sulfate's bioavailability and efficacy, making it a more effective and targeted chemotherapeutic agent.
There are many suppliers of Vincristine sulfate on the LookChem platform, such as HENAN NEW BLUE CHEMICAL CO.,LTD, Dayang Chem (Hangzhou) Co.,Ltd., Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd. Through the form on the right, you can choose to send an inquiry to your intended factory. We recommend that you clearly describe your purchase requirements, for example: Vincristine sulfate CAS number 2068-78-2 with a purity of over 98% that needs to be transported to Los Angeles, USA.
Here are some small packages of Vincristine sulfate price information you can contact us to purchase, if you need to purchase Vincristine sulfate in bulk, please send an inquiry message to get the latest prices and offers.
| Name | CAS | Size | Price(USD) |
| MACKLIN | 2068-78-2 | 500.00mg | 478.51 |
| MACKLIN | 2068-78-2 | 25.00mg | 56.72 |
| MACKLIN | 2068-78-2 | 10.00mg | 80.60 |
| MACKLIN | 2068-78-2 | 100.00mg | 141.79 |
| Acmec | 2068-78-2 | 25.00mg | 192.24 |
| Acmec | 2068-78-2 | 5.00mg | 42.99 |
| Acmec | 2068-78-2 | 1.00g | 682.09 |
| Acmec | 2068-78-2 | 100.00mg | 160.45 |
| Acmec | 2068-78-2 | 250.00mg | 273.73 |
| Acmec | 2068-78-2 | 50.00mg | 128.51 |
| Acmec | 2068-78-2 | 20.00mg | 141.49 |
| RHAWN | 2068-78-2 | 100.00mg | 160.60 |
| RHAWN | 2068-78-2 | 25.00mg | 60.90 |
| ALADDIN | 2068-78-2 | 500.00mg | 533.13 |
| ALADDIN | 2068-78-2 | 100.00mg | 163.73 |
| ALADDIN | 2068-78-2 | 10.00mg | 81.19 |
| ALADDIN | 2068-78-2 | 25.00mg | 62.24 |
| Boer | 2068-78-2 | 25.00mg | 59.70 |
| Boer | 2068-78-2 | 100.00mg | 145.07 |
| Boer | 2068-78-2 | 500.00mg | 496.57 |
| Psaitong | 2068-78-2 | 20.00mg | 89.55 |
| Psaitong | 2068-78-2 | 25.00mg | 41.79 |
| Psaitong | 2068-78-2 | 100.00mg | 130.60 |
| J&K | 2068-78-2 | 10.00mg | 248.21 |