Chemicals used in pain management
Chemicals used in inflammation reduction
Indomethacin is a traditional NSAID with effective analgesic, antipyretic and anti-inflammatory activity. It is an indole-acetic acid derivative available since the 1960s and probably one of the most potent compounds also derived from the acetic acid as diclofenac and sulindac. Not surprisingly, indomethacin was among the first NSAID used to treat headache in clinical practice including migraine and headache syndromes eventually known as “indomethacin-responsive” headaches. In addition to the inhibition of cyclooxygenase, preventing the production of prostaglandins from arachidonic acid, indomethacin has a unique action that is not yet clarified. It may interfere with iontophoresed glutamate-activated dural-responsive second order neurons in the Trigeminal Nucleus Caudalis (TCC). Nonsteroidal anti-inflammatory drugs, cyclooxygenase inhibitors, are used routinely in the treatment of primary headache disorders. Moreover, indomethacin may modulate nitric oxide (NO) signaling pathways. Nitric oxide is known to induce headache and delayed migraine in patients. In preclinical studies, indomethacin is able to inhibit NO-induced dural vasodilation, and this effect is unique because other NSAID also used for migraine such as naproxen or ibuprofen were ineffective in this regard.
There are many suppliers of Indometacin on the LookChem platform, such as Zibo Hangyu Biotechnology Development Co., Ltd, LIDE PHARMACEUTICALS LIMITED, Dayang Chem (Hangzhou) Co.,Ltd.. Through the form on the right, you can choose to send an inquiry to your intended factory. We recommend that you clearly describe your purchase requirements, for example: Indometacin CAS number 53-86-1 with a purity of over 98% that needs to be transported to Los Angeles, USA.
Here are some small packages of Indometacin price information you can contact us to purchase, if you need to purchase Indometacin in bulk, please send an inquiry message to get the latest prices and offers.
| Name | CAS | Size | Price(USD) |
| MACKLIN | 53-86-1 | 10.00kg | 1347.01 |
| MACKLIN | 53-86-1 | 2.50kg | 378.21 |
| MACKLIN | 53-86-1 | 5.00g | 6.87 |
| MACKLIN | 53-86-1 | 500.00g | 113.58 |
| MACKLIN | 53-86-1 | 25.00g | 14.78 |
| MACKLIN | 53-86-1 | 100.00g | 35.52 |
| Acmec | 53-86-1 | 250.00mg | 28.06 |
| Acmec | 53-86-1 | 100.00g | 29.55 |
| Acmec | 53-86-1 | 25.00g | 11.64 |
| Acmec | 53-86-1 | 5.00g | 5.52 |
| Boer | 53-86-1 | 500.00G | 474.63 |
| Boer | 53-86-1 | 100.00G | 162.69 |
| Boer | 53-86-1 | 25.00G | 72.39 |
| Boer | 53-86-1 | 100.00g | 34.03 |
| Boer | 53-86-1 | 25.00g | 14.18 |
| Boer | 53-86-1 | 2.50kg | 448.21 |
| Boer | 53-86-1 | 5.00g | 6.57 |
| Boer | 53-86-1 | 500.00g | 112.54 |
| Psaitong | 53-86-1 | 5.00g | 5.97 |
| Psaitong | 53-86-1 | 100.00g | 33.43 |
| Psaitong | 53-86-1 | 25.00g | 11.94 |
| MAYA | 53-86-1 | 100.00MG | 22.39 |